There are the following contraindications when using natamycin lactose preparations:
I. Contraindications Related to Allergy
Allergy to Natamycin: If a patient is allergic to natamycin itself, using a natamycin lactose preparation may trigger allergic reactions, such as rashes, itching, difficulty breathing, facial swelling, etc. In severe cases, anaphylactic shock may even occur. Such people should be strictly prohibited from using it.
Allergy or Intolerance to Lactose: Since the preparation contains lactose, for patients with lactose intolerance or allergy, after using it, they may experience gastrointestinal discomfort symptoms, such as abdominal pain, diarrhea, abdominal distension, etc. Such people are also not suitable for using it.
II. Contraindications in Special Disease Conditions
Severe Hepatic and Renal Insufficiency: Natamycin is mainly metabolized by the liver and excreted through the kidneys. In patients with severe hepatic and renal insufficiency, their liver and kidney functions cannot normally metabolize and excrete the drug, which may lead to drug accumulation in the body and increase the risk of adverse drug reactions. Generally, it is not recommended to use it. It can only be used cautiously when, under the close monitoring and evaluation of a doctor, the benefits are considered to outweigh the risks.
Certain Ocular Diseases: When used for the eyes, if there are serious conditions such as severe corneal ulcers or the ocular infection is in the acute progressive stage, using a natamycin lactose preparation may affect the observation of the disease condition or aggravate local irritation, etc. It is necessary to carefully evaluate before deciding whether to use it.
III. Contraindications for Special Populations
Pregnant Women: Currently, the research on the safety of natamycin lactose preparations in pregnant women is not sufficient. In order to avoid potential risks that may be posed to the fetus, pregnant women should, under the guidance of a doctor, weigh the pros and cons before deciding whether to use it.
Lactating Women: Similarly, for lactating women, it is not clear whether the drug will be secreted through breast milk and what impact it will have on the nursing infant. Generally, it is also recommended to use it cautiously under the guidance of a doctor. If necessary, breastfeeding should be suspended during the period of use.
Children: The organ functions of children have not been fully developed, and their tolerance and reaction to the drug may be different from those of adults. When using natamycin lactose preparations, more caution is required. The dosage and usage method should be adjusted according to factors such as the child's age and weight, and the doctor's instructions should be strictly followed.
The above contraindications are only general principles. When using it specifically, it is still necessary to make judgments and decisions under the guidance of a doctor or a pharmacist according to the individual situation of the patient.