Product Name: Streptomycin Sulfate

Molecular Formula: C21H41N7O16S

CAS Number: 3810-74-0

Features:

Streptomycin Sulfate is effective against both Gram-positive and Gram-negative bacteria, with particularly good efficacy against tuberculosis and various Gram-negative bacteria. It is used to treat acute infections caused by susceptible bacteria in pigs, including respiratory tract infections (such as pneumonia, pharyngitis, and bronchitis), urinary tract infections, actinomycosis, leptospirosis, bacterial gastroenteritis, and bacterial enteritis.

Compliance:

The product complies with the standards of the Chinese Pharmacopoeia, Chinese Veterinary Pharmacopoeia, EP, USP, and has obtained certification from the European CEP and the US FDA.

Storage:

Store in a dark, sealed, and dry place.

Streptomycin Sulfate Introduction

Streptomycin Sulfate: An Overview

Streptomycin Sulfate is a widely used antibiotic medication that belongs to the aminoglycoside class of antibiotics. It is used to treat a wide range of bacterial infections in both humans and animals. Streptomycin Sulfate has been in use for more than 60 years, and its efficacy and safety have been well established through extensive research and clinical trials.

History and Development of Streptomycin Sulfate

Streptomycin was first isolated from the soil bacterium Streptomyces griseus in 1943 by scientists Selman Waksman and Albert Schatz at Rutgers University. It was the first antibiotic medication discovered that could effectively treat tuberculosis, a disease that was widespread and often fatal at the time. Streptomycin was also found to be effective against other bacterial infections, such as bacterial endocarditis and brucellosis.

Streptomycin Sulfate was developed as a more stable and soluble form of the antibiotic in the 1950s. The sulfate form of the drug was found to be more effective and less toxic than the original streptomycin formulation. Since then, Streptomycin Sulfate has become a widely used antibiotic medication for the treatment of a variety of bacterial infections.

Mechanism of Action

Streptomycin Sulfate works by inhibiting bacterial protein synthesis, which is necessary for the growth and survival of bacteria. It binds to the bacterial ribosome, preventing the formation of the initiation complex that is necessary for protein synthesis to occur. This leads to the inhibition of bacterial growth and the eventual death of the bacteria.

Streptomycin Sulfate is effective against both Gram-positive and Gram-negative bacteria. It is particularly effective against Mycobacterium tuberculosis, the bacteria that causes tuberculosis, as well as other Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

Uses and Applications

Streptomycin Sulfate is used to treat a wide range of bacterial infections in both humans and animals. In humans, it is most commonly used to treat tuberculosis, as well as other infections caused by Mycobacterium species. It is also used to treat infections caused by other bacteria, such as Brucella species, Francisella tularensis, and Yersinia pestis.

In animals, Streptomycin Sulfate is used to treat a variety of infections caused by susceptible bacteria, including respiratory tract infections, urinary tract infections, actinomycosis, leptospirosis, bacterial gastroenteritis, and bacterial enteritis.

Dosage and Administration

The dosage and administration of Streptomycin Sulfate will vary depending on the type of infection being treated, the age and weight of the patient, and other factors. In humans, the usual adult dosage for tuberculosis is 15 mg/kg/day, given intramuscularly or intravenously. In animals, the dosage will vary depending on the species, the severity of the infection, and other factors.

Side Effects and Precautions

Like all medications, Streptomycin Sulfate can cause side effects in some patients. The most common side effects include hearing loss, kidney damage, and nerve damage. These side effects are more likely to occur with long-term or high-dose use of the medication.

Patients with pre-existing kidney or hearing problems may be more susceptible to the side effects of Streptomycin Sulfate. The medication should be used with caution in these patients, and dosage adjustments may be necessary.

Patients should also be monitored closely for signs of allergic reactions, such as rash, itching, or difficulty breathing. If any of these symptoms occur, the medication should be discontinued immediately and medical attention should be sought.

It is important to note that Streptomycin Sulfate is not effective against all types of bacterial infections. It should only be used to treat infections caused by susceptible bacteria, as inappropriate use of antibiotics can lead to the development of antibiotic resistance.

Streptomycin Sulfate should not be used in patients with known hypersensitivity to aminoglycoside antibiotics. It should also be used with caution in patients with myasthenia gravis, as the medication can exacerbate the symptoms of this condition.

Storage and Handling

Streptomycin Sulfate should be stored in a cool, dry place, protected from light. It should be kept in its original packaging until ready for use. The medication should not be frozen or exposed to extreme heat.

In addition, Streptomycin Sulfate should be handled with care, as it is a hazardous substance. It should only be handled by trained personnel using appropriate personal protective equipment.

Regulatory Status

Streptomycin Sulfate is approved for use in humans and animals by regulatory agencies around the world, including the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). The medication is available in various formulations, including injectable solutions and powders for oral administration.

Conclusion

Streptomycin Sulfate is a well-established antibiotic medication that has been used for more than 60 years to treat a wide range of bacterial infections in both humans and animals. Its efficacy and safety have been well established through extensive research and clinical trials. While the medication can cause side effects in some patients, it is generally considered safe and effective when used appropriately. As with all antibiotics, it is important to use Streptomycin Sulfate only for the treatment of infections caused by susceptible bacteria, and to use it with caution in patients with pre-existing kidney or hearing problems.