Supply High Purity Nisin,Bacteriostatic Mechanism

Nisin, also known as lactococcin, is a natural antimicrobial peptide produced by the fermentation of Lactococcus lactis. It has a broad-spectrum antibacterial effect, effectively inhibiting the growth and reproduction of most Gram-positive bacteria and their spores, particularly against common pathogens such as Staphylococcus aureus, Streptococcus pyogenes, and Clostridium botulinum. Consequently, it is widely used in the food industry as a preservative.

1. Mechanism of Action

·Adsorption and Pore Formation:

Nisin specifically adsorbs to bacterial cell membranes. It forms pores or channels in the cell membrane, allowing intracellular substances (such as ions and small molecules) to leak out while permitting extracellular water molecules to enter the cell.

·Cell Lysis and Death:

The formation of pores disrupts the osmotic balance inside and outside the cell, leading to cell lysis. The loss of nutrients and the decline in membrane potential ultimately result in the death of pathogenic and spoilage bacteria.

2. Antimicrobial Characteristics

·Target Specificity:

Nisin primarily targets Gram-positive bacteria, especially bacterial spores, and has no inhibitory effect on Gram-negative bacteria, yeasts, or molds.

·High Safety:

In the human gut, nisin is quickly hydrolyzed by pancreatic proteases into amino acids, posing no adverse effects on the normal gut microbiota. Nisin does not exhibit resistance issues or cross-resistance like other antibiotics.

·Wide Application:

Nisin is widely used in dairy products, canned foods, fish products, and alcoholic beverages to ensure hygiene and extend shelf life.

In recent years, as research on nisin has deepened, its potential applications in food preservation, medicine, and animal feed have been recognized. Additionally, studies are focused on increasing the yield and reducing the cost of nisin production to promote broader applications.

Nisin interferes with the normal function of bacterial cell membranes, causing permeability and nutrient loss, ultimately leading to the death of pathogenic and spoilage bacteria. Its unique mechanism of action is highly targeted, with significant safety and wide application prospects.