Biomedical-grade ε-Polylysine hydrochloride


Biomedical-grade ε-Polylysine hydrochloride is a peptide compound with specific biochemical/physiological properties, also known as polylysine, L-polylysine, or polylysine hydrobromide. This compound demonstrates unique application values in multiple fields.

Biomedical-grade ε-Polylysine hydrochloride exhibits pharmacological activity in promoting neuronal growth. Using mice as a biological research model, ε-Polylysine hydrochloride positively impacts the growth of primary hippocampal neurons in newborn mice. Additionally, as a novel antibacterial agent, it possesses broad-spectrum antibacterial properties with high safety levels.  In the field of food preservation, it shows great application prospects.

Furthermore, ε-Polylysine hydrochloride serves as a nonspecific adhesive factor. By enhancing the electrostatic interaction between cell membranes and negatively charged ions on the culture surface, it promotes cell adhesion to solid substrates. When absorbed onto the cell culture surface, its function is to increase the number of available positively charged sites for cell binding.

ε-Polylysine hydrochloride can also be applied in the preparation of functional factor carriers and the synthesis of artificial antigens. It is also used as an efficient transfection reagent for high-efficiency labeling and promoting phagocytosis.

From a chemical structure perspective, ε-Polylysine hydrochloride is a positively charged amino acid polymer, with approximately one HBr per lysine residue. The presence of hydrobromic acid salts allows Poly-L-lysine to form a water-soluble crystalline form. However, it should be noted that a small amount of product may be found in β structures, as HBr may interfere with hydrogen bonding between amino and carboxyl groups or parts containing N or O.

Due to its unique biochemical/physiological effects, biomedical-grade ε-Polylysine hydrochloride has extensive application prospects in medicine, food, biotechnology, and other fields.