Derived from nature, nisin offers higher naturalness and safety compared to synthetic preservatives. Its molecular structure is stable and not easily destroyed by human digestive enzymes, meaning it does not produce harmful substances in the body, ensuring its safe use.
Nisin can effectively inhibit the growth of harmful microorganisms such as Staphylococcus aureus and Escherichia coli, which are major causes of common human diseases like food poisoning and intestinal infections. Thus, nisin plays a positive role in protecting human health.
The median lethal dose (LD50) of nisin for mice is approximately 7000 mg per kg of body weight, similar to that of common table salt, classifying it as non-toxic. This indicates that under normal usage conditions, nisin is safe for humans.
Nisin is permitted as a food preservative in more than 60 countries and regions, including internationally and in Europe, the United States, Australia, New Zealand, and Japan. This wide international acceptance further demonstrates its safety.
Nisin has minimal impact on the environment and human gut flora. After ingestion, it is degraded into amino acids by proteases in the body and absorbed without affecting the intestinal microbiota. It also degrades quickly in the natural environment, making its environmental impact minimal.
With the increasing focus on health and the pursuit of natural and safe preservatives, nisin, as a natural, safe, and efficient biopreservative, has broad application prospects in the food and pharmaceutical industries. As a natural antimicrobial peptide, it is characterized by a stable molecular structure, strong antibacterial effect, and low toxicity. Its safety has been widely recognized and it has been extensively used internationally. In the food and pharmaceutical sectors, nisin can serve as an alternative to synthetic chemical preservatives, providing consumers with safer and healthier food choices.