High-quality Nisin Quotation,China Manufacturers

The entire process of producing and applying nisin as a natural food preservative requires strict quality control to ensure product safety and effectiveness. Below are comprehensive quality control measures from production to application:

I. Quality Control in the Production Process

·Selection and Storage of Raw Materials

Raw Material Quality: Selecting high-quality, sterile raw materials is a critical step in preventing contamination. Raw materials should meet relevant standards and requirements, ensuring no harmful residues are present.

Storage Conditions: Raw materials should be kept dry, well-ventilated, and regularly cleaned and disinfected during storage. The storage environment should maintain appropriate temperature and humidity levels to prevent microbial growth and reproduction.

·Production Equipment and Environment

Equipment Cleaning and Disinfection: Before production, all equipment and tools must be thoroughly cleaned and disinfected to remove any residual dirt and microorganisms. Disinfectants with broad-spectrum antimicrobial effects, such as Okta-TS disinfectant, should be used to ensure the sterility of equipment and tools.

Environmental Hygiene: The production workshop should be kept clean and disinfected regularly. The air in the workshop should be filtered and purified to remove dust and microorganisms, and the temperature and humidity should be controlled to prevent microbial growth and reproduction.

·Process Control in Production

Inoculation and Aeration: Inoculate the lactic acid bacteria strain into the bioreactor and introduce sterile air to provide sufficient oxygen for the strain. The inoculation amount and aeration rate should be strictly controlled to ensure normal growth of the strain and synthesis of nisin.

Stirring and Temperature Control: Stir the culture medium in the bioreactor to ensure uniform distribution of the strain and adequate oxygen supply. Temperature control of the bioreactor is essential to provide an optimal growth environment for the strain, promoting nisin synthesis.

Fermentation and Extraction: Cultivate lactic acid bacteria in the bioreactor to secrete nisin. After fermentation, extract nisin and by-products through specific extraction processes.

·Monitoring and Recording

Process Monitoring: Real-time monitoring of key parameters, including temperature, pH value, and oxygen concentration, is necessary to ensure production stability and controllability.

Record Management: Detailed recording and management of the production process, including raw material usage, equipment operation status, and changes in production parameters, help in identifying and addressing issues promptly.

II. Quality Control in the Application Process

·Usage Control

According to different food types and processing needs, the amount of nisin used should be reasonably controlled. Refer to standards like GB2760-2014 to ensure the usage amount is within a safe range.

·Usage Method

Nisin is typically added to food in solution form. It should be dissolved in distilled water or cooled boiled water to about a 5% solution before being thoroughly mixed into the food. Ensuring even distribution of nisin in the food achieves the best preservative effect.

·Storage Conditions

The product should be stored in a cool, ventilated, clean, and dry place. It should be protected from direct sunlight and high temperatures, and avoid mixing with toxic, harmful, and corrosive substances to prevent cross-contamination.

III. Comprehensive Quality Control Measures

·Personnel Training

Production personnel should receive professional training to master microbiological knowledge and operational skills, ensuring hygiene and safety during the production process.

·Quality Testing

Regular inspection and evaluation of the production environment and equipment ensure they are in good hygienic condition. Quality testing of the produced nisin ensures it meets relevant standards and requirements.

·Continuous Improvement

Continuously optimizing production processes and quality control measures based on actual production conditions and market demand changes improves product quality and market competitiveness.

Comprehensive quality control from production to application, involving multiple aspects and stages, ensures the safety and effectiveness of nisin products by strictly controlling raw material quality, production equipment and environment, production process control, and application methods.