ε-Polylysine Hydrochloride in drugs,Safe & Effective

ε-Polylysine hydrochloride demonstrates significant synergistic effects in enhancing drug efficacy. It exhibits notable inhibitory effects on a wide range of microorganisms, including Gram-positive bacteria, Gram-negative bacteria, yeasts, and molds. Its broad-spectrum antibacterial property allows it to be used in combination with various drugs, thereby expanding the antimicrobial spectrum and enhancing the overall therapeutic effect.

When used in combination with other natural or chemical preservatives (such as acetic acid, ethanol, glycine, organic acids, etc.), ε-polylysine hydrochloride exhibits a synergistic effect that significantly improves antibacterial efficacy. This synergy helps reduce the required dosage of drugs, lower drug residues, and increase the safety of food or pharmaceuticals.

ε-Polylysine hydrochloride is rich in cations and has a strong electrostatic interaction with anionic substances. It also exhibits good penetration into biofilms, making it a potential carrier for certain drugs, facilitating the penetration of drug molecules through cell membranes and improving the bioavailability of the drugs. By combining with drugs, ε-polylysine hydrochloride can modify the drug release rate, allowing for sustained release within the body, thus prolonging the drug's action and enhancing therapeutic outcomes.

The compound is thermally stable, as it does not decompose at high temperatures (e.g., 121°C for 30 minutes), which ensures that it retains its activity during thermal processing of pharmaceuticals, maintaining drug stability and efficacy. Additionally, it exhibits strong antibacterial properties across a wide pH range (pH 2–9), enabling it to remain active in pharmaceutical systems of different pH values, thus improving drug stability and compatibility.

Combining ε-polylysine hydrochloride with methotrexate (a drug used to treat leukemia and tumors) can enhance the drug's efficacy, improve its targeting to tumor cells, increase therapeutic effects, and reduce side effects. In the development of antibacterial drugs, combining ε-polylysine hydrochloride with other antibacterial agents can result in new drugs with enhanced antibacterial effects, which can be used to treat infections caused by multiple microorganisms, improving therapeutic efficacy and reducing drug resistance.

In summary, ε-polylysine hydrochloride exhibits significant synergistic effects in enhancing drug efficacy by enhancing antibacterial effects, improving bioavailability, increasing drug stability, and serving as a drug carrier. These mechanisms contribute to improving the overall efficacy and safety of drugs.