In veterinary practice, colistin sulfate can be used to treat various diseases caused by susceptible bacteria, primarily focusing on infections of the digestive and respiratory systems in animals. Below are some common indications:

·Digestive Tract Infections: Colistin sulfate has strong antibacterial activity against Gram-negative bacteria in the intestines, making it commonly used to treat digestive tract infections in animals (such as pigs, cattle, sheep, poultry, etc.) including enteritis, diarrhea, and dysentery. These infections are often caused by Escherichia coli and Salmonella, and colistin sulfate can effectively control the condition and promote animal recovery.

·Respiratory Infections: Colistin sulfate is also used to treat respiratory infections in animals, such as pneumonia and bronchitis. These diseases can be caused by various bacteria, including strains resistant to commonly used antibiotics. Its broad-spectrum antibacterial properties make it an effective choice for treating these conditions.

·Urinary Tract Infections: Colistin sulfate can be used for treating urinary tract infections in animals, such as cystitis and urethritis, which may be caused by susceptible bacteria. It is excreted through urine and can inhibit or kill the bacteria causing the infection in the urinary tract.

·Other Infections: In some cases, colistin sulfate may also be used to treat skin infections, eye infections, and other conditions in animals. However, these uses are less common and should be determined by a veterinarian based on the specific situation.

Although colistin sulfate has a broad antibacterial spectrum, it is not effective against all bacteria. Therefore, bacterial culture and sensitivity testing are necessary before use to identify the pathogen and its sensitivity to colistin sulfate. The use of colistin sulfate should strictly follow the veterinarian's prescription and instructions to avoid overdosing or misuse, which could cause harm to the animal or lead to antibiotic resistance.

Colistin sulfate has broad application prospects in veterinary medicine, but it must be used under the guidance of a veterinarian to ensure its safety and effectiveness.