Product
​Nisin Supplier
  • Createtime: 2023-03-24
  • Updatetime: 2024-10-16
Product Details
Nisin, also known as lactococcal peptide or transliterated as Nisin, is a natural bioactive antimicrobial peptide.

1. Basic Properties

·Source of Production: Nisin is a polyfunctional substance produced by Lactococcus lactis, composed of 34 amino acid residues with a molecular weight of approximately 3500 Da.

·Appearance: Nisin appears as a white to pale yellow powder and can sometimes be presented as a light brown solid powder.

·Solubility: The solubility of nisin in water depends on the pH. Under acidic conditions (e.g., at pH 2.5), its solubility is 12%; however, under neutral or alkaline conditions, its solubility decreases and may even be insoluble in water.

2. Antimicrobial Action

·Broad-Spectrum Antibacterial Activity: Nisin has strong inhibitory effects against most Gram-positive bacteria, such as Staphylococcus aureus, Streptococcus pyogenes, Listeria monocytogenes, and Bacillus cereus.

·Inhibition of Spores: Nisin exhibits strong inhibitory effects specifically against spore-forming Gram-positive bacteria, such as Bacillus and Clostridium species.

·Mechanism of Action: The antimicrobial action of nisin disrupts the normal function of the cell membrane, leading to increased permeability, nutrient loss, and a decline in membrane potential, which ultimately causes the death of pathogenic and spoilage bacteria.

3. Safety and Applications

·Safety: Nisin is quickly hydrolyzed into amino acids under physiological pH conditions and the action of pancreatic enzymes after consumption. It does not alter the normal intestinal flora in humans and does not produce resistance problems associated with other antibiotics. Furthermore, it does not exhibit cross-resistance with other antibiotics, making it an efficient, non-toxic, safe, and side-effect-free natural food preservative.

·Applications: Due to its excellent antimicrobial properties and safety, nisin is widely used in the food industry as a preservative for meat products, dairy products, canned goods, fish products, and alcoholic beverages. Additionally, in the pharmaceutical field, nisin is utilized in the development of antimicrobial drugs.

4. Storage and Stability

·Storage Conditions: Nisin should be stored in a cool, dry, and sealed environment at 4-15°C, avoiding direct sunlight.

·Stability: The stability of nisin is related to the pH of the solution. Under acidic conditions (e.g., at pH 2), it has good heat resistance; however, its heat resistance decreases when the pH exceeds 5.

Nisin is a natural food preservative with broad-spectrum antibacterial properties, high efficiency, non-toxicity, safety, and no side effects, making it widely applicable in the food and pharmaceutical fields.


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