Feed-grade chlortetracycline, commonly referred to as feed-grade aureomycin, is a form of chlortetracycline mainly used as a feed additive.

I. Definition and Composition

Feed-grade chlortetracycline, or feed-grade aureomycin, mainly consists of chlortetracycline calcium salt. It is prepared by mixing the entire fermentation broth with an appropriate amount of calcium carbonate. It typically appears as brown or dark brown powder or granules, free of caking or mold, and odorless.

II. Source and Preparation

Feed-grade aureomycin is an antibiotic extracted through the fermentation of Streptomyces aureofaciens. The fermentation process involves biotechnology, where specific culture conditions and fermentation techniques allow the production of chlortetracycline by Streptomyces aureofaciens. Through a series of extraction, purification, and formulation processes, feed-grade aureomycin is obtained.

III. Functions and Uses

·Antibacterial Action: Feed-grade aureomycin has broad-spectrum antibacterial activity, capable of inhibiting the growth and reproduction of various bacteria, including Gram-positive bacteria, Gram-negative bacteria, and mycoplasma. This makes it highly significant for the prevention and treatment of animal diseases.

·Growth Promotion: Feed-grade aureomycin also promotes animal growth and improves feed conversion rates. By enhancing the intestinal environment, it increases the absorption and utilization of nutrients, leading to increased weight gain and faster growth in animals.

·Feed Additive: In China, feed-grade aureomycin is widely used as a feed additive. It boosts the immune system of animals, reduces disease occurrence, and improves feed efficiency and animal growth performance.

IV. Usage Precautions

·Dosage Control: When using feed-grade aureomycin, strict control of dosage is necessary. Overuse may lead to excessive residue in animals, posing potential health risks to humans.

·Withdrawal Period: A specific withdrawal period must be observed before animals are sold or slaughtered to ensure the residual level of chlortetracycline in animals meets food safety standards.

·Drug Interactions: Feed-grade aureomycin may have interactions with other antibiotics or chemical drugs. Therefore, concurrent use with other medications should be avoided to prevent adverse reactions.

Feed-grade chlortetracycline (feed-grade aureomycin) is an important feed additive with broad-spectrum antibacterial and growth-promoting effects. However, dosage control and observing the withdrawal period are crucial to ensure its safety and effectiveness.